Across TCGA patient cohorts, IGSF23 protein abundance is significantly associated with the RNA expression of many other genes, with 233 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGSF23-associated genes across cancer lineages are APOL4, CHD8, and MAX. Each is linked with IGSF23 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGSF23-to-partner and partner-to-IGSF23 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF23→partner) and Y-score (partner→IGSF23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	APOL4 →	+2.803	+2.493	.006	<.001	3	1
BRCA	CHD8 →	+0.759	+2.112	.006	<.001	3	1
BRCA	MAX →	+0.644	+2.112	<.001	<.001	3	1
BRCA	RNF112 →	+1.020	+2.493	.003	<.001	3	1
BRCA	MNX1 →	+1.880	+2.493	.009	<.001	3	1
BRCA	EPHB2 →	+1.180	+2.493	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 233 associations by consensus.

Exploration

IGSF23 survival (RNA) · tumor vs normal (RNA) · all IGSF23 data types