Across TCGA patient cohorts, IGSF23 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGSF23-associated genes across cancer lineages are RN7SL248P, SPATA31D4, and RNU1-28P. Each is linked with IGSF23 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGSF23-to-partner and partner-to-IGSF23 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF23→partner) and Y-score (partner→IGSF23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.299	+6.722	<.001	<.001	3	1
UCEC	SPATA31D4 →	+0.019	+6.123	<.001	.002	3	1
UCEC	RNU1-28P →	+0.496	+5.484	.006	.005	3	1
UCEC	RNU6-1145P →	+1.378	+5.186	<.001	.007	3	1
UCEC	ATF1P1 →	+0.184	+5.081	.001	.008	3	1
UCEC	LINC02644 →	+0.489	+5.484	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

IGSF23 survival (RNA) · tumor vs normal (RNA) · all IGSF23 data types