IGSF11

Across TCGA patient cohorts, IGSF11 mutation is significantly associated with the RNA expression of many other genes, with 4,228 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGSF11-associated genes across cancer lineages are RN7SKP186, RNU6-986P, and LINC02736. Each is linked with IGSF11 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGSF11-to-partner and partner-to-IGSF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP186 grouped by IGSF11-low versus IGSF11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGSF11→partner) and Y-score (partner→IGSF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SKP186 →	+0.168	+4.771	<.001	.006	3	3
BLCA	RNU6-986P →	+0.504	+5.255	<.001	<.001	3	3
COAD	LINC02736 →	+0.287	+4.196	<.001	.004	3	3
UCEC	LINC01399 →	+0.189	+1.898	<.001	<.001	3	3
UCEC	RNA5SP417 →	+0.552	+2.351	<.001	<.001	3	3
UCEC	RNA5SP415 →	+0.594	+2.723	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,228 associations by consensus.

RN7SKP186 by IGSF11 expression — SKCM

Explore this box plot interactively →