Across TCGA patient cohorts, IGLV8-61 mutation is significantly associated with the RNA expression of many other genes, with 78 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGLV8-61-associated genes across cancer lineages are MTND2P33, RPL7L1P4, and LARP7P1. Each is linked with IGLV8-61 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGLV8-61-to-partner and partner-to-IGLV8-61 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV8-61→partner) and Y-score (partner→IGLV8-61) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MTND2P33 →	+0.038	+4.116	.003	.004	3	2
COAD	RPL7L1P4 →	+0.218	+5.080	<.001	.008	3	2
UCEC	LARP7P1 →	+0.309	+3.771	<.001	.003	3	1
UCEC	RN7SL248P →	+0.124	+4.400	<.001	.006	3	1
SKCM	MTND1P29 →	+0.057	+5.199	.002	.003	3	1
UCEC	OR2M5 →	+0.061	+4.132	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

Exploration

IGLV8-61 survival (RNA) · tumor vs normal (RNA) · all IGLV8-61 data types