Across TCGA patient cohorts, IGLV5-52 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGLV5-52-associated genes across cancer lineages are MIR3666, OR5AO1P, and MRGPRX8P. Each is linked with IGLV5-52 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGLV5-52-to-partner and partner-to-IGLV5-52 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV5-52→partner) and Y-score (partner→IGLV5-52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR3666 →	+0.396	+4.538	<.001	.006	3	1
UCEC	OR5AO1P →	+0.178	+4.352	<.001	.008	3	1
SKCM	MRGPRX8P →	+0.055	+5.680	<.001	.003	3	1
SKCM	RPL12P43 →	+0.080	+5.436	<.001	.005	3	1
SKCM	HSPE1P16 →	+0.130	+5.513	<.001	.004	3	1
SKCM	RN7SL632P →	+0.172	+5.867	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

IGLV5-52 survival (RNA) · tumor vs normal (RNA) · all IGLV5-52 data types