MAS related GPR family member X8, pseudogeneGenealiases: []
Q-omics provides the consensus-scored MRGPRX8P profile across patient tissues and cancer cell-line models. MRGPRX8P expression is associated with patient survival in 7 of 34 cancer types, with the highest sampling consensus in COAD. Among the 18 cancer types available for tumor–normal comparison, MRGPRX8P is differentially expressed in 1, with the highest sampling consensus in PRAD. Additionally, MRGPRX8P RNA expression shows 7,041 significant gene co-expression associations, with the highest sampling consensus in COAD. Together, these results highlight COAD, and PRAD as cancer lineages where MRGPRX8P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MRGPRX8P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MRGPRX8P survival associations across molecular data types. MRGPRX8P RNA expression shows survival associations in the most cancer types (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MRGPRX8P RNA expression–survival associations across cancer types. High MRGPRX8P expression shows unfavorable associations in COAD, OV, LUSC, TGCT and PCPG, but favorable associations in HNSC. The COAD Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify COAD as the clearest survival context for MRGPRX8P RNA expression.
This table summarizes MRGPRX8P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 1. The strongest signals are observed in PRAD for RNA.
This table ranks reproducible tumor–normal expression differences for MRGPRX8P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MRGPRX8P shows higher tumor expression in PRAD. The PRAD box plot shows higher MRGPRX8P RNA expression in tumor versus normal tissue (log2 FC = +0.009, t-test p = .022).
This table shows molecular features associated with MRGPRX8P in patient tissues and cancer cell lines. In patient samples, MRGPRX8P shows the broadest associations at the RNA and protein expression levels, with COAD recurring as the lineage with the largest associated feature set.
