Across TCGA patient cohorts, IGLV3-12 mutation is significantly associated with the RNA expression of many other genes, with 64 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGLV3-12-associated genes across cancer lineages are MIR548H3, RNU6-866P, and PPP1R2P5. Each is linked with IGLV3-12 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGLV3-12-to-partner and partner-to-IGLV3-12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV3-12→partner) and Y-score (partner→IGLV3-12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR548H3 →	+0.459	+3.299	<.001	.006	3	2
SKCM	RNU6-866P →	+0.269	+2.769	.005	.008	3	2
SKCM	PPP1R2P5 →	+0.030	+4.039	.002	.009	3	2
UCEC	MRPS17P5 →	+0.216	+4.242	<.001	.006	3	1
LGG	OR10R3P →	+0.064	+7.977	<.001	.007	3	1
LGG	MIR610 →	+0.318	+7.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

Exploration

IGLV3-12 survival (RNA) · tumor vs normal (RNA) · all IGLV3-12 data types