Across TCGA pan-cancer cohorts, IGLV3-12 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of IGLV3-12’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGLV3-12 RNA is repressed in tumor relative to normal tissue. In most cancer types IGLV3-12 is over-expressed in tumor, although a few such as COAD and LIHC show the opposite, repressed pattern.

COAD, LUAD, and KIRC are the cancer types where IGLV3-12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGLV3-12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	−1.077	<.001	10	view →
LUAD	Female	All	+1.688	<.001	8	view →
KIRC	All	All	+0.665	<.001	6	view →
LIHC	Male	All	−0.266	.001	4	view →
READ	All	All	−1.032	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: IGLV3-12 RNA expression & survival · all IGLV3-12 data types