IGLV1-41

Across TCGA patient cohorts, IGLV1-41 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGLV1-41-associated genes across cancer lineages are CCDC75P1, RNU6-805P, and MIR6816. Each is linked with IGLV1-41 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGLV1-41-to-partner and partner-to-IGLV1-41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC75P1 grouped by IGLV1-41-low versus IGLV1-41-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV1-41→partner) and Y-score (partner→IGLV1-41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CCDC75P1 →	+0.055	+4.563	.006	.004	3	2
SKCM	RNU6-805P →	+0.265	+4.771	<.001	.006	3	2
SKCM	MIR6816 →	+0.418	+4.594	<.001	.008	3	2
HNSC	RNU6-1325P →	+0.338	+7.954	<.001	.008	3	1
HNSC	MIR512-2 →	+0.363	+7.954	<.001	.008	3	1
HNSC	RNU7-51P →	+0.512	+7.954	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

CCDC75P1 by IGLV1-41 expression — SKCM

Explore this box plot interactively →