IGLV1-41

Across TCGA pan-cancer cohorts, IGLV1-41 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of IGLV1-41’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGLV1-41 RNA is repressed in tumor relative to normal tissue. In most cancer types IGLV1-41 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and KIRC are the cancer types where IGLV1-41 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGLV1-41 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−2.232	<.001	7	view →
LUAD	Female	All	+1.474	<.001	6	view →
KIRC	Male	All	+0.739	<.001	4	view →
BRCA	Female	All	−0.461	.020	4	view →
READ	All	All	−2.483	.002	3	view →
ESCA	All	II,III,IV	+1.250	.041	2	view →
LIHC	Male	All	−0.502	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

IGLV1-41–COAD

Open the COAD breakdown →