IGLV1-41

Across TCGA pan-cancer cohorts, IGLV1-41 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated IGLV1-41 data layer compared with 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGLV1-41 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGLV1-41 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UCS are the cancer types where IGLV1-41 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.738	0.583	<.001	141	view →
SKCM	OS	Median	II,III,IV	0.925	0.757	<.001	71	view →
UCS	OS	Tertile	II,III,IV	0.665	0.240	.003	64	view →
BRCA	OS	Quartile	All	0.667	0.493	<.001	47	view →
LIHC	DFS	Median	II,III,IV	0.470	0.198	<.001	33	view →
LUSC	DFS	Quartile	III,IV	0.837	0.431	<.001	24	view →
GBM	OS	Tertile	All	0.223	0.467	<.001	18	view →
UCEC	DFS	Tertile	All	0.774	0.527	.024	14	view →
KIRP	DFS	Quartile	All	0.473	0.841	.013	12	view →
KICH	DFS	Tertile	II,III,IV	0.436	0.906	.017	10	view →
PAAD	DFS	Median	II,III,IV	0.374	0.213	.007	10	view →
PCPG	OS	Median	All	0.852	1.000	.022	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

IGLV1-41–HNSC (DFS)

Open the HNSC breakdown →