IGKV7-3

RNA expression — cross-omics
Cross-omicsRNA → FUNCTION-RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, IGKV7-3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,994 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IGKV7-3-associated GO terms across cancer lineages are Humoral immune response mediated by circulating immunoglobulin, B cell receptor signaling pathway, and Complement activation, classical pathway. Each is linked with IGKV7-3 in more than 29 cancer types. Because this analysis shows association rather than direction, both IGKV7-3-to-partner and partner-to-IGKV7-3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV7-3→partner) and Y-score (partner→IGKV7-3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner GO termX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
THCAHumoral immune response mediated by circulating immunoglobulin →+0.165+0.937<.001<.001330
CHOLB cell receptor signaling pathway →+0.115+1.060<.001.001328
THCAComplement activation, classical pathway →+0.199+0.952<.001<.001328
CHOLB cell mediated immunity →+0.100+1.171<.001<.001328
CHOLInterleukin-12 production →+0.062+1.116<.001.001328
CHOLAntigen receptor-mediated signaling pathway →+0.078+1.319<.001<.001228
Each partner links to its Q-omics profile. Showing the 6 strongest of 6,994 associations by consensus.

Exploration