Across TCGA patient cohorts, IGKV6D-21 protein abundance is significantly associated with the RNA expression of many other genes, with 74 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible IGKV6D-21-associated genes across cancer lineages are WNT2, RNF17, and TSHB. Each is linked with IGKV6D-21 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV6D-21-to-partner and partner-to-IGKV6D-21 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV6D-21→partner) and Y-score (partner→IGKV6D-21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	WNT2 →	+0.870	+1.920	<.001	.007	3	1
LUAD	RNF17 →	-0.160	-2.074	.007	.008	3	1
LUAD	TSHB →	+0.253	+1.458	.004	.007	3	1
LUAD	S100A3 →	+1.720	+2.074	.009	.008	3	1
LUAD	RNU6-1251P →	+1.126	+1.458	<.001	.007	3	1
LUAD	NOTCH4 →	+1.100	+2.080	.004	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

Exploration

IGKV6D-21 survival (RNA) · tumor vs normal (RNA) · all IGKV6D-21 data types