IGKV3OR22-2

Across TCGA patient cohorts, IGKV3OR22-2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,125 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IGKV3OR22-2-associated GO terms across cancer lineages are B cell mediated immunity, Antibacterial humoral response, and Antigen receptor-mediated signaling pathway. Each is linked with IGKV3OR22-2 in more than 22 cancer types. Because this analysis shows association rather than direction, both IGKV3OR22-2-to-partner and partner-to-IGKV3OR22-2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell mediated immunity grouped by IGKV3OR22-2-low versus IGKV3OR22-2-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV3OR22-2→partner) and Y-score (partner→IGKV3OR22-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	B cell mediated immunity →	+0.100	+0.433	<.001	<.001	3	23
THCA	Antibacterial humoral response →	+0.161	+0.405	<.001	<.001	3	22
SKCM	Antigen receptor-mediated signaling pathway →	+0.054	+0.203	<.001	<.001	3	22
ESCA	Immunoglobulin production →	+0.078	+0.105	<.001	<.001	3	21
SKCM	B cell receptor signaling pathway →	+0.071	+0.200	<.001	<.001	3	21
SKCM	Alpha-beta T cell activation →	+0.051	+0.203	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,125 associations by consensus.

B cell mediated immunity by IGKV3OR22-2 expression — THCA

Explore this box plot interactively →