IGKV3OR22-2

Across TCGA pan-cancer cohorts, IGKV3OR22-2 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated IGKV3OR22-2 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher IGKV3OR22-2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV3OR22-2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

UVM, SKCM, and HNSC are the cancer types where IGKV3OR22-2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.104	0.858	<.001	99	view →
SKCM	OS	Tertile	III,IV	0.702	0.248	.002	42	view →
HNSC	OS	Quartile	All	0.779	0.652	.011	40	view →
STAD	OS	Tertile	II,III,IV	0.701	0.488	.035	27	view →
PAAD	OS	Tertile	II,III,IV	0.697	0.482	.009	18	view →
MESO	OS	Tertile	III,IV	0.532	0.293	.019	18	view →
LGG	OS	Tertile	All	0.190	0.450	.008	18	view →
LIHC	OS	Tertile	II,III,IV	0.406	0.709	.004	15	view →
THCA	OS	Tertile	IV	0.813	1.000	.039	9	view →
KIRC	DFS	Tertile	II,III,IV	0.949	0.777	.020	6	view →
CESC	OS	Tertile	All	0.935	0.846	.034	4	view →
READ	DFS	Tertile	IV	0.820	0.497	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

IGKV3OR22-2–UVM (OS)

Open the UVM breakdown →