IGKV3D-25

Across TCGA pan-cancer cohorts, IGKV3D-25 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated IGKV3D-25 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IGKV3D-25 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV3D-25 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, HNSC, and ESCA are the cancer types where IGKV3D-25 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	III,IV	0.832	0.481	.001	72	view →
HNSC	DFS	Tertile	III,IV	0.814	0.635	.006	69	view →
ESCA	DFS	Tertile	III,IV	0.663	0.252	.009	57	view →
TGCT	OS	Tertile	II,III,IV	0.501	0.996	<.001	54	view →
KIRP	OS	Tertile	All	0.702	0.902	<.001	39	view →
BLCA	DFS	Tertile	All	0.724	0.275	.008	36	view →
CESC	DFS	Tertile	II,III,IV	0.664	0.432	.037	12	view →
LAML	DFS	Tertile	All	0.675	0.329	.045	12	view →
LUAD	DFS	Median	All	0.744	0.622	.017	10	view →
LIHC	OS	Tertile	III,IV	0.117	0.535	.020	9	view →
THCA	DFS	Tertile	All	0.793	0.929	.048	3	view →
LUSC	OS	Quartile	II,III,IV	0.288	0.629	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

IGKV3D-25–UCEC (DFS)

Open the UCEC breakdown →