IGKV3D-25

Across TCGA pan-cancer cohorts, IGKV3D-25 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of IGKV3D-25’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where IGKV3D-25 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV3D-25 is over-expressed in tumor, although a few such as STAD and COAD show the opposite, repressed pattern.

STAD, LUAD, and COAD are the cancer types where IGKV3D-25 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV3D-25 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	Male	All	−0.661	.008	6	view →
LUAD	All	All	+0.305	<.001	5	view →
COAD	All	IV	−0.674	.020	3	view →
READ	All	III,IV	−0.600	.021	2	view →
BRCA	All	All	−0.080	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

IGKV3D-25–STAD

Open the STAD breakdown →