Across TCGA patient cohorts, IGKV3D-20 mutation is significantly associated with the RNA expression of many other genes, with 88 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible IGKV3D-20-associated genes across cancer lineages are GTF2IP3, RNU6-1155P, and RNA5S9. Each is linked with IGKV3D-20 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV3D-20-to-partner and partner-to-IGKV3D-20 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV3D-20→partner) and Y-score (partner→IGKV3D-20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GTF2IP3 →	+0.982	+5.070	<.001	.008	3	2
LUSC	RNU6-1155P →	+0.127	+4.102	<.001	.007	3	2
SKCM	RNA5S9 →	+0.164	+4.039	<.001	.009	3	2
UCEC	RN7SL248P →	+0.302	+6.722	<.001	<.001	3	1
HNSC	RNU6-1078P →	+0.278	+7.954	<.001	.008	3	1
HNSC	RNU6-159P →	+0.274	+7.954	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 88 associations by consensus.

Exploration

IGKV3D-20 survival (RNA) · tumor vs normal (RNA) · all IGKV3D-20 data types