Across TCGA pan-cancer cohorts, IGKV3D-20 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated IGKV3D-20 data layer compared with 8 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV3D-20 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV3D-20 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, BRCA, and SKCM are the cancer types where IGKV3D-20 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.779	0.641	<.001	144	view →
BRCA	DFS	Median	All	0.969	0.927	<.001	75	view →
SKCM	OS	Median	II,III,IV	0.409	0.217	.002	57	view →
UVM	OS	Quartile	II,III,IV	0.339	0.746	.004	43	view →
UCEC	OS	Median	II,III,IV	0.746	0.278	<.001	42	view →
KIRP	OS	Median	All	0.573	0.789	.002	41	view →
SARC	DFS	Median	All	0.589	0.431	.001	36	view →
COAD	OS	Tertile	IV	0.793	0.215	.001	33	view →
KIRC	DFS	Median	All	0.723	0.865	.004	28	view →
LUAD	OS	Tertile	II,III,IV	0.757	0.491	.003	18	view →
CHOL	DFS	Tertile	All	0.780	0.231	.002	15	view →
MESO	OS	Tertile	All	0.730	0.226	.019	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

Exploration

Same gene, other analysis: IGKV3D-20 tumor-vs-normal RNA expression · all IGKV3D-20 data types