IGKV3-20

Across TCGA patient cohorts, IGKV3-20 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,500 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGKV3-20-associated proteins across cancer lineages are MZB1, HCLS1, and ISG20. Each is linked with IGKV3-20 in more than 9 cancer types. Because this analysis shows association rather than direction, both IGKV3-20-to-partner and partner-to-IGKV3-20 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGKV3-20 versus MZB1 in OV, with a Pearson correlation of 0.73.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV3-20→partner) and Y-score (partner→IGKV3-20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MZB1 →	+1.601	+4.365	<.001	<.001	3	10
GBM	HCLS1 →	+0.584	+2.256	<.001	<.001	3	10
BRCA	ISG20 →	+0.828	+2.694	<.001	<.001	3	10
GBM	LCP1 →	+0.721	+2.305	<.001	<.001	3	10
BRCA	ARHGAP25 →	+0.542	+2.945	<.001	<.001	3	9
GBM	ARHGAP45 →	+0.520	+2.341	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,500 associations by consensus.

IGKV3-20 vs MZB1 — OV

Explore this scatter interactively →