IGKV3-20

Across TCGA patient cohorts, IGKV3-20 mutation is significantly associated with the RNA expression of many other genes, with 75 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible IGKV3-20-associated genes across cancer lineages are RNU6-207P, BSNDP1, and RPL31P41. Each is linked with IGKV3-20 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGKV3-20-to-partner and partner-to-IGKV3-20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-207P grouped by IGKV3-20-low versus IGKV3-20-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV3-20→partner) and Y-score (partner→IGKV3-20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-207P →	+0.493	+5.343	<.001	.006	3	3
BLCA	BSNDP1 →	+0.147	+5.722	<.001	.001	3	2
SKCM	RPL31P41 →	+0.132	+3.913	.003	.006	3	2
SKCM	TRAJ33 →	+1.100	+5.043	<.001	<.001	3	2
BLCA	RN7SKP193 →	+0.571	+4.162	<.001	.003	3	1
UCEC	RNU6-1290P →	+0.580	+5.464	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

RNU6-207P by IGKV3-20 expression — LUAD

Explore this box plot interactively →