IGKV3-15

Across TCGA patient cohorts, IGKV3-15 mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGKV3-15-associated genes across cancer lineages are OR2D2, LCN1P2, and MIR4462. Each is linked with IGKV3-15 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV3-15-to-partner and partner-to-IGKV3-15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2D2 grouped by IGKV3-15-low versus IGKV3-15-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV3-15→partner) and Y-score (partner→IGKV3-15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	OR2D2 →	+0.108	+4.532	.001	.005	3	1
LUSC	LCN1P2 →	+0.268	+4.715	.002	.003	3	1
LUSC	MIR4462 →	+0.795	+5.417	<.001	<.001	3	1
SKCM	FAM247B →	+0.180	+5.163	.004	.001	3	1
LUAD	MRPL57P6 →	+0.199	+7.930	<.001	.008	3	1
UCEC	RN7SKP135 →	+0.173	+8.066	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

OR2D2 by IGKV3-15 expression — LUSC

Explore this box plot interactively →