IGKV3-15

Across TCGA pan-cancer cohorts, IGKV3-15 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated IGKV3-15 data layer compared with 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV3-15 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV3-15 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UCEC are the cancer types where IGKV3-15 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.785	0.633	<.001	143	view →
SKCM	OS	Median	All	0.413	0.269	<.001	113	view →
UCEC	OS	Tertile	III,IV	0.739	0.331	<.001	80	view →
BRCA	DFS	Tertile	All	0.592	0.490	.001	63	view →
LIHC	DFS	Median	II,III,IV	0.453	0.199	.004	45	view →
COAD	DFS	Tertile	III,IV	0.732	0.322	.004	31	view →
SARC	OS	Quartile	All	0.828	0.597	<.001	29	view →
KIRC	DFS	Tertile	All	0.587	0.704	.011	26	view →
CESC	OS	Tertile	All	0.873	0.736	.008	22	view →
OV	OS	Median	II,III,IV	0.381	0.280	.017	22	view →
LGG	OS	Quartile	All	0.721	0.843	.001	21	view →
MESO	OS	Quartile	III,IV	0.793	0.131	.017	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

IGKV3-15–HNSC (DFS)

Open the HNSC breakdown →