IGKV3-11

Across TCGA patient cohorts, IGKV3-11 protein abundance is significantly associated with the RNA expression of many other genes, with 5,654 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGKV3-11-associated genes across cancer lineages are MTX2, PHB, and TGM2. Each is linked with IGKV3-11 in more than 3 cancer types. Because this analysis shows association rather than direction, both IGKV3-11-to-partner and partner-to-IGKV3-11 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGKV3-11 versus MTX2 in LSCC, with a Pearson correlation of -0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV3-11→partner) and Y-score (partner→IGKV3-11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MTX2 →	-0.462	-0.383	<.001	.001	3	4
BRCA	PHB →	-0.501	-0.669	.004	<.001	3	4
LSCC	TGM2 →	+1.181	+0.391	<.001	.001	3	4
OV	IGKJ3 →	+3.200	+0.811	<.001	<.001	3	4
LSCC	IGLL5 →	+1.110	+0.515	<.001	<.001	3	4
BRCA	MRPS34 →	-0.659	-0.767	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,654 associations by consensus.

IGKV3-11 vs MTX2 — LSCC

Explore this scatter interactively →