IGKV3-11

Across TCGA pan-cancer cohorts, IGKV3-11 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of IGKV3-11’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV3-11 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV3-11 is over-expressed in tumor, although a few such as COAD and LIHC show the opposite, repressed pattern.

COAD, LUAD, and LIHC are the cancer types where IGKV3-11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV3-11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−2.742	<.001	9	view →
LUAD	All	III,IV	+2.442	<.001	8	view →
LIHC	Male	All	−3.083	<.001	4	view →
KIRC	Male	All	+1.975	<.001	4	view →
KICH	All	II,III,IV	−2.120	.012	3	view →
READ	All	All	−3.808	.002	2	view →
HNSC	Female	III,IV	+2.527	.028	2	view →
BRCA	Female	II,III,IV	−0.718	.032	2	view →
LUSC	All	All	+0.934	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

IGKV3-11–COAD

Open the COAD breakdown →