IGKV3-11

Across TCGA pan-cancer cohorts, IGKV3-11 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated IGKV3-11 data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV3-11 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV3-11 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where IGKV3-11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.664	0.542	<.001	144	view →
SKCM	OS	Median	All	0.412	0.272	<.001	121	view →
BRCA	OS	Quartile	All	0.976	0.936	.002	43	view →
UCEC	OS	Median	III,IV	0.692	0.444	.004	42	view →
COAD	DFS	Median	All	0.763	0.625	.001	38	view →
KIRC	DFS	Quartile	All	0.431	0.719	.003	34	view →
UVM	DFS	Tertile	II,III,IV	0.369	0.814	.012	29	view →
LIHC	DFS	Median	II,III,IV	0.500	0.351	.010	26	view →
UCS	OS	Tertile	II,III,IV	0.705	0.297	.006	24	view →
CESC	OS	Median	All	0.857	0.734	.006	22	view →
SARC	OS	Tertile	All	0.639	0.399	<.001	22	view →
LUAD	DFS	Tertile	II,III,IV	0.569	0.316	.030	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

IGKV3-11–HNSC (DFS)

Open the HNSC breakdown →