IGKV3-11

Across TCGA patient cohorts, IGKV3-11 mutation is significantly associated with the RNA expression of many other genes, with 214 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGKV3-11-associated genes across cancer lineages are SNORD56B, RNU6-535P, and ETDA. Each is linked with IGKV3-11 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV3-11-to-partner and partner-to-IGKV3-11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD56B grouped by IGKV3-11-low versus IGKV3-11-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV3-11→partner) and Y-score (partner→IGKV3-11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SNORD56B →	+0.836	+4.822	<.001	.006	3	2
LUSC	RNU6-535P →	+0.345	+5.081	<.001	.004	3	2
HNSC	ETDA →	+0.133	+4.245	<.001	.008	3	2
HNSC	RNU6-75P →	+0.645	+5.608	<.001	.002	3	2
HNSC	COX6B1P6 →	+0.340	+5.709	<.001	<.001	3	2
HNSC	MIR3139 →	+0.589	+5.063	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 214 associations by consensus.

SNORD56B by IGKV3-11 expression — HNSC

Explore this box plot interactively →