IGKV2OR22-3

Across TCGA patient cohorts, IGKV2OR22-3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,865 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGKV2OR22-3-associated GO terms across cancer lineages are Humoral immune response mediated by circulating immunoglobulin, B cell receptor signaling pathway, and Complement activation. Each is linked with IGKV2OR22-3 in more than 26 cancer types. Because this analysis shows association rather than direction, both IGKV2OR22-3-to-partner and partner-to-IGKV2OR22-3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Humoral immune response mediated by circulating immunoglobulin grouped by IGKV2OR22-3-low versus IGKV2OR22-3-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2OR22-3→partner) and Y-score (partner→IGKV2OR22-3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	Humoral immune response mediated by circulating immunoglobulin →	+0.158	+0.845	<.001	<.001	3	27
ESCA	B cell receptor signaling pathway →	+0.075	+0.467	<.001	<.001	3	26
THCA	Complement activation →	+0.147	+0.855	<.001	<.001	3	26
THCA	Complement activation, classical pathway →	+0.188	+0.857	<.001	<.001	3	26
THCA	Humoral immune response →	+0.061	+0.847	<.001	<.001	3	26
THCA	Antibacterial humoral response →	+0.165	+0.912	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,865 associations by consensus.

Humoral immune response mediated by circulating immunoglobulin by IGKV2OR22-3 expression — THCA

Explore this box plot interactively →