IGKV2OR22-3

Across TCGA pan-cancer cohorts, IGKV2OR22-3 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated IGKV2OR22-3 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV2OR22-3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV2OR22-3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CESC show a favorable association.

HNSC, CESC, and SKCM are the cancer types where IGKV2OR22-3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.752	0.619	<.001	144	view →
CESC	OS	Median	All	0.882	0.711	<.001	90	view →
SKCM	OS	Median	All	0.869	0.696	<.001	78	view →
BRCA	OS	Median	All	0.975	0.949	<.001	69	view →
GBM	OS	Tertile	All	0.248	0.424	.010	27	view →
UCS	OS	Tertile	II,III,IV	0.652	0.260	.019	24	view →
STAD	DFS	Tertile	All	0.590	0.711	.018	20	view →
LGG	DFS	Tertile	All	0.605	0.833	.008	15	view →
KIRP	DFS	Quartile	All	0.529	0.860	.005	14	view →
PAAD	OS	Quartile	II,III,IV	0.747	0.419	.025	12	view →
THYM	DFS	Quartile	III,IV	0.386	0.892	.009	12	view →
UCEC	OS	Quartile	III,IV	0.920	0.783	.020	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

IGKV2OR22-3–HNSC (DFS)

Open the HNSC breakdown →