IGKV2OR2-8

Across TCGA patient cohorts, IGKV2OR2-8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,457 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IGKV2OR2-8-associated GO terms across cancer lineages are B cell mediated immunity, Immunoglobulin production, and Antigen receptor-mediated signaling pathway. Each is linked with IGKV2OR2-8 in more than 12 cancer types. Because this analysis shows association rather than direction, both IGKV2OR2-8-to-partner and partner-to-IGKV2OR2-8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell mediated immunity grouped by IGKV2OR2-8-low versus IGKV2OR2-8-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2OR2-8→partner) and Y-score (partner→IGKV2OR2-8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	B cell mediated immunity →	+0.111	+0.091	<.001	<.001	3	13
THCA	Immunoglobulin production →	+0.080	+0.093	<.001	<.001	3	13
THCA	Antigen receptor-mediated signaling pathway →	+0.062	+0.085	<.001	<.001	3	12
THCA	B cell receptor signaling pathway →	+0.083	+0.085	<.001	<.001	3	11
THCA	Antibacterial humoral response →	+0.157	+0.085	<.001	<.001	3	11
THCA	Negative T cell selection →	+0.082	+0.072	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,457 associations by consensus.

B cell mediated immunity by IGKV2OR2-8 expression — THCA

Explore this box plot interactively →