IGKV2OR2-8

Across TCGA pan-cancer cohorts, IGKV2OR2-8 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of IGKV2OR2-8’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV2OR2-8 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV2OR2-8 is over-expressed in tumor, although a few such as COAD and STAD show the opposite, repressed pattern.

COAD, STAD, and LUAD are the cancer types where IGKV2OR2-8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV2OR2-8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	−0.092	.002	4	view →
STAD	Male	IV	−0.375	.037	2	view →
LUAD	All	All	+0.078	.009	2	view →
LUSC	All	All	+0.054	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

IGKV2OR2-8–COAD

Open the COAD breakdown →