IGKV2OR2-8

Across TCGA pan-cancer cohorts, IGKV2OR2-8 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated IGKV2OR2-8 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV2OR2-8 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGKV2OR2-8 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, UCEC, and SKCM are the cancer types where IGKV2OR2-8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.720	0.362	.001	141	view →
UCEC	DFS	Tertile	All	0.388	0.843	<.001	102	view →
SKCM	DFS	Tertile	All	0.407	0.192	.007	48	view →
LUAD	DFS	Tertile	II,III,IV	0.745	0.503	.008	30	view →
PAAD	DFS	Tertile	All	0.228	0.492	<.001	27	view →
BLCA	DFS	Tertile	All	0.709	0.316	.015	21	view →
KIRC	DFS	Tertile	IV	0.217	0.603	.013	18	view →
GBM	DFS	Tertile	All	0.048	0.257	.001	18	view →
COAD	OS	Tertile	IV	0.188	0.670	.007	18	view →
LAML	DFS	Tertile	All	1.000	0.534	.031	12	view →
KIRP	OS	Tertile	II,III,IV	0.492	0.832	.035	3	view →
LIHC	DFS	Tertile	All	1.000	0.543	.043	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

IGKV2OR2-8–HNSC (OS)

Open the HNSC breakdown →