IGKV2OR2-2

Across TCGA patient cohorts, IGKV2OR2-2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,945 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGKV2OR2-2-associated GO terms across cancer lineages are B cell mediated immunity, Immunoglobulin production, and B cell receptor signaling pathway. Each is linked with IGKV2OR2-2 in more than 23 cancer types. Because this analysis shows association rather than direction, both IGKV2OR2-2-to-partner and partner-to-IGKV2OR2-2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell mediated immunity grouped by IGKV2OR2-2-low versus IGKV2OR2-2-high in SARC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2OR2-2→partner) and Y-score (partner→IGKV2OR2-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	B cell mediated immunity →	+0.126	+0.068	<.001	.003	3	24
SARC	Immunoglobulin production →	+0.097	+0.094	<.001	.004	1	24
SKCM	B cell receptor signaling pathway →	+0.096	+0.219	<.001	<.001	3	20
SKCM	B cell differentiation →	+0.067	+0.223	<.001	<.001	3	19
SKCM	B cell activation →	+0.057	+0.198	<.001	<.001	3	19
SKCM	Leukocyte apoptotic process →	+0.051	+0.210	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,945 associations by consensus.

B cell mediated immunity by IGKV2OR2-2 expression — SARC

Explore this box plot interactively →