IGKV2OR2-2

Across TCGA pan-cancer cohorts, IGKV2OR2-2 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated IGKV2OR2-2 data layer.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher IGKV2OR2-2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGKV2OR2-2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and TGCT show a favorable association.

STAD, ACC, and GBM are the cancer types where IGKV2OR2-2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Tertile	II,III,IV	0.471	0.654	.005	81	view →
ACC	OS	Tertile	All	0.113	0.822	<.001	63	view →
GBM	OS	Tertile	All	0.058	0.416	<.001	36	view →
KIRP	DFS	Tertile	All	0.527	0.799	.007	33	view →
SKCM	DFS	Tertile	All	0.891	0.724	.021	18	view →
TGCT	DFS	Tertile	All	0.962	0.756	.016	18	view →
LIHC	OS	Tertile	III,IV	0.079	0.737	.004	18	view →
LUAD	DFS	Median	All	0.738	0.622	.016	14	view →
READ	OS	Tertile	II,III,IV	1.000	0.580	.028	12	view →
PAAD	OS	Tertile	II,III,IV	0.861	0.402	.026	9	view →
CESC	OS	Tertile	All	0.894	0.770	.039	6	view →
DLBC	DFS	Quartile	All	1.000	0.519	.039	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

IGKV2OR2-2–STAD (DFS)

Open the STAD breakdown →