IGKV2OR2-2

Across TCGA pan-cancer cohorts, IGKV2OR2-2 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of IGKV2OR2-2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV2OR2-2 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV2OR2-2 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, READ, and STAD are the cancer types where IGKV2OR2-2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV2OR2-2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−0.544	<.001	10	view →
READ	All	All	−0.373	.002	3	view →
STAD	Male	All	−0.263	.004	3	view →
CHOL	All	II,III,IV	−0.295	.007	2	view →
LUAD	All	All	+0.142	.005	2	view →
BRCA	All	III,IV	−0.121	.017	2	view →
LIHC	All	All	−0.022	.027	2	view →
HNSC	All	IV	−0.100	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

IGKV2OR2-2–COAD

Open the COAD breakdown →