IGKV2D-40

Across TCGA pan-cancer cohorts, IGKV2D-40 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated IGKV2D-40 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV2D-40 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGKV2D-40 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where IGKV2D-40 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.741	0.580	<.001	144	view →
SKCM	OS	Tertile	All	0.434	0.271	<.001	108	view →
BRCA	OS	Quartile	All	0.623	0.532	<.001	64	view →
CESC	OS	Tertile	All	0.877	0.712	.002	50	view →
KIRP	OS	Quartile	All	0.331	0.780	<.001	27	view →
CHOL	DFS	Tertile	All	0.766	0.227	.001	24	view →
STAD	DFS	Quartile	All	0.534	0.717	.014	22	view →
SARC	OS	Tertile	All	0.623	0.454	.005	20	view →
BLCA	DFS	Quartile	III,IV	0.630	0.479	.017	15	view →
TGCT	DFS	Median	All	0.909	0.753	.016	14	view →
LAML	DFS	Median	All	0.512	0.230	.009	10	view →
GBM	OS	Tertile	All	0.189	0.428	.033	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

IGKV2D-40–HNSC (OS)

Open the HNSC breakdown →