IGKV2D-40

Across TCGA pan-cancer cohorts, IGKV2D-40 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of IGKV2D-40’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where IGKV2D-40 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IGKV2D-40 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

LUAD, COAD, and BRCA are the cancer types where IGKV2D-40 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV2D-40 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	+1.979	<.001	8	view →
COAD	Female	III,IV	−3.110	<.001	6	view →
BRCA	Female	II,III,IV	−0.611	.035	4	view →
LIHC	Male	All	−0.894	.001	3	view →
READ	Female	All	−1.938	.025	2	view →
ESCA	All	All	+1.567	.011	2	view →
HNSC	All	III,IV	+1.152	.037	1	view →
KIRC	All	All	+0.599	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

IGKV2D-40–LUAD

Open the LUAD breakdown →