IGKV2D-30

Across TCGA patient cohorts, IGKV2D-30 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,978 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IGKV2D-30-associated GO terms across cancer lineages are B cell receptor signaling pathway, Positive regulation of leukocyte proliferation, and Respiratory burst. Each is linked with IGKV2D-30 in more than 27 cancer types. Because this analysis shows association rather than direction, both IGKV2D-30-to-partner and partner-to-IGKV2D-30 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell receptor signaling pathway grouped by IGKV2D-30-low versus IGKV2D-30-high in CHOL.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2D-30→partner) and Y-score (partner→IGKV2D-30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	B cell receptor signaling pathway →	+0.101	+0.737	<.001	.001	3	28
CHOL	Positive regulation of leukocyte proliferation →	+0.064	+1.097	<.001	.001	3	28
SARC	Respiratory burst →	+0.079	+0.287	<.001	<.001	3	28
SARC	Antimicrobial humoral response →	+0.104	+0.317	<.001	<.001	3	28
ESCA	Positive regulation of tumor necrosis factor superfamily cytokine production →	+0.067	+1.233	<.001	<.001	3	27
CHOL	Regulation of leukocyte apoptotic process →	+0.071	+0.966	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,978 associations by consensus.

B cell receptor signaling pathway by IGKV2D-30 expression — CHOL

Explore this box plot interactively →