IGKV2D-30

Across TCGA pan-cancer cohorts, IGKV2D-30 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated IGKV2D-30 data layer compared with 1 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV2D-30 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGKV2D-30 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, BRCA, and ACC are the cancer types where IGKV2D-30 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.724	0.598	<.001	144	view →
BRCA	DFS	Tertile	All	0.972	0.913	<.001	94	view →
ACC	DFS	Tertile	III,IV	0.010	0.458	<.001	63	view →
SKCM	OS	Tertile	All	0.448	0.300	.002	57	view →
CESC	DFS	Median	II,III,IV	0.786	0.605	.012	46	view →
UVM	OS	Tertile	II,III,IV	0.189	0.728	.002	45	view →
GBM	OS	Tertile	All	0.278	0.451	<.001	36	view →
THYM	OS	Tertile	All	0.917	1.000	.001	35	view →
CHOL	DFS	Tertile	All	0.692	0.275	.026	27	view →
PAAD	OS	Median	II,III,IV	0.651	0.453	.004	18	view →
DLBC	OS	Quartile	All	0.457	1.000	.002	17	view →
BLCA	DFS	Median	All	0.448	0.216	.020	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

IGKV2D-30–HNSC (OS)

Open the HNSC breakdown →