IGKV2D-30

Across TCGA pan-cancer cohorts, IGKV2D-30 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of IGKV2D-30’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV2D-30 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV2D-30 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, BRCA, and LUAD are the cancer types where IGKV2D-30 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV2D-30 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−2.822	<.001	10	view →
BRCA	Female	II,III,IV	−0.600	<.001	6	view →
LUAD	All	All	+1.114	<.001	5	view →
KIRC	All	All	+0.386	.001	4	view →
READ	All	All	−2.119	<.001	3	view →
STAD	All	IV	−3.576	.018	2	view →
ESCA	All	II,III,IV	+3.115	.017	2	view →
LIHC	Male	All	−0.263	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

IGKV2D-30–COAD

Open the COAD breakdown →