IGKV2D-30

Across TCGA patient cohorts, IGKV2D-30 protein abundance is significantly associated with the RNA expression of many other genes, with 976 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGKV2D-30-associated genes across cancer lineages are HRK, HTATSF1, and LONP2. Each is linked with IGKV2D-30 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV2D-30-to-partner and partner-to-IGKV2D-30 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGKV2D-30 versus HRK in GBM, with a Pearson correlation of -0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2D-30→partner) and Y-score (partner→IGKV2D-30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HRK →	-0.957	-0.928	.001	.008	3	2
GBM	HTATSF1 →	-0.343	-0.826	.001	.001	3	1
GBM	LONP2 →	-0.355	-0.741	.001	.005	3	1
GBM	GIMAP2 →	+0.747	+0.821	.004	.002	3	1
GBM	SLC25A11 →	-0.386	-0.965	.002	.005	3	1
GBM	PCCB →	-0.316	-0.828	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 976 associations by consensus.

IGKV2D-30 vs HRK — GBM

Explore this scatter interactively →