IGKV2D-30

Across TCGA patient cohorts, IGKV2D-30 mutation is significantly associated with the RNA expression of many other genes, with 122 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGKV2D-30-associated genes across cancer lineages are RNA5SP384, MIR8059, and RRM1-AS1. Each is linked with IGKV2D-30 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV2D-30-to-partner and partner-to-IGKV2D-30 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP384 grouped by IGKV2D-30-low versus IGKV2D-30-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2D-30→partner) and Y-score (partner→IGKV2D-30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNA5SP384 →	+0.160	+5.277	<.001	.001	3	2
UCEC	MIR8059 →	+0.968	+4.386	<.001	.002	3	2
SKCM	RRM1-AS1 →	+0.189	+3.635	.006	.008	3	1
SKCM	MIR4767 →	+0.722	+3.530	.002	.007	3	1
LUAD	LYZL2 →	+0.782	+3.303	<.001	.004	3	1
LUAD	OBP2B →	+0.389	+3.671	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 122 associations by consensus.

RNA5SP384 by IGKV2D-30 expression — LUAD

Explore this box plot interactively →