IGKV2D-29

Across TCGA patient cohorts, IGKV2D-29 protein abundance is significantly associated with the RNA expression of many other genes, with 11,008 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGKV2D-29-associated genes across cancer lineages are IGKV2-29, IGKV2-26, and IGKV6D-21. Each is linked with IGKV2D-29 in more than 8 cancer types. Because this analysis shows association rather than direction, both IGKV2D-29-to-partner and partner-to-IGKV2D-29 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGKV2D-29 versus IGKV2-29 in PDAC, with a Pearson correlation of 0.61.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2D-29→partner) and Y-score (partner→IGKV2D-29) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	IGKV2-29 →	+3.958	+0.977	<.001	<.001	3	9
HNSC	IGKV2-26 →	+1.065	+0.392	<.001	.009	3	7
PDAC	IGKV6D-21 →	+1.774	+0.757	<.001	<.001	3	6
OV	IGKV3-20 →	+3.969	+0.933	<.001	<.001	3	5
HNSC	AMPD1 →	+0.885	+0.447	.007	.009	3	4
OV	FASTKD2 →	-0.361	-0.614	.007	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,008 associations by consensus.

IGKV2D-29 vs IGKV2-29 — PDAC

Explore this scatter interactively →