IGKV2D-29

Across TCGA pan-cancer cohorts, IGKV2D-29 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated IGKV2D-29 data layer compared with 6 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV2D-29 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGKV2D-29 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, BRCA, and COAD are the cancer types where IGKV2D-29 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.462	0.294	<.001	138	view →
BRCA	DFS	Quartile	All	0.657	0.461	<.001	60	view →
COAD	OS	Median	All	0.871	0.748	.002	46	view →
SKCM	OS	Median	III,IV	0.934	0.728	.001	38	view →
UCEC	DFS	Median	III,IV	0.707	0.394	.001	38	view →
LIHC	OS	Tertile	All	0.817	0.705	.005	24	view →
STAD	OS	Median	IV	0.642	0.203	.006	24	view →
SARC	DFS	Quartile	All	0.662	0.465	.003	24	view →
UVM	DFS	Quartile	All	0.364	0.661	.007	18	view →
ACC	DFS	Tertile	III,IV	0.095	0.431	.015	15	view →
READ	DFS	Quartile	IV	0.889	0.452	.010	14	view →
CESC	OS	Median	II,III,IV	0.896	0.745	.018	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

IGKV2D-29–HNSC (OS)

Open the HNSC breakdown →