IGKV2D-29

Across TCGA patient cohorts, IGKV2D-29 mutation is significantly associated with the RNA expression of many other genes, with 113 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible IGKV2D-29-associated genes across cancer lineages are COTL1P2, IGHD3-16, and SSX2B. Each is linked with IGKV2D-29 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV2D-29-to-partner and partner-to-IGKV2D-29 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COTL1P2 grouped by IGKV2D-29-low versus IGKV2D-29-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2D-29→partner) and Y-score (partner→IGKV2D-29) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	COTL1P2 →	+0.192	+3.787	<.001	.002	3	2
UCEC	IGHD3-16 →	+1.717	+4.417	.001	.001	3	2
LUSC	SSX2B →	+0.066	+4.626	<.001	<.001	3	2
SKCM	DEFB117 →	+0.361	+5.970	<.001	.002	3	2
SKCM	RNA5SP369 →	+0.395	+6.993	<.001	<.001	3	2
UCEC	PIGPP4 →	+0.323	+3.488	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 113 associations by consensus.

COTL1P2 by IGKV2D-29 expression — LUAD

Explore this box plot interactively →