IGKV2D-19

Across TCGA patient cohorts, IGKV2D-19 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,426 significant associations in total. STAD shows the largest number of these associations.

The most reproducible IGKV2D-19-associated GO terms across cancer lineages are B cell mediated immunity, Cotranslational protein targeting to membrane, and Immunoglobulin production. Each is linked with IGKV2D-19 in more than 11 cancer types. Because this analysis shows association rather than direction, both IGKV2D-19-to-partner and partner-to-IGKV2D-19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell mediated immunity grouped by IGKV2D-19-low versus IGKV2D-19-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2D-19→partner) and Y-score (partner→IGKV2D-19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	B cell mediated immunity →	+0.108	+0.020	<.001	<.001	3	12
STAD	Cotranslational protein targeting to membrane →	+0.092	+0.171	<.001	<.001	3	9
LIHC	Immunoglobulin production →	+0.080	+0.028	<.001	.006	2	10
STAD	Granulocyte differentiation →	+0.087	+0.200	<.001	<.001	3	9
STAD	T cell receptor signaling pathway →	+0.082	+0.164	<.001	<.001	3	9
ESCA	Lymphocyte apoptotic process →	+0.090	+0.246	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,426 associations by consensus.

B cell mediated immunity by IGKV2D-19 expression — THCA

Explore this box plot interactively →