IGKV2D-19

Across TCGA pan-cancer cohorts, IGKV2D-19 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated IGKV2D-19 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher IGKV2D-19 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGKV2D-19 expression acts as an unfavorable survival marker.

KICH, KIRP, and SKCM are the cancer types where IGKV2D-19 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	All	0.081	0.904	<.001	90	view →
KIRP	OS	Tertile	All	0.305	0.726	<.001	63	view →
SKCM	OS	Tertile	II,III,IV	0.175	0.739	<.001	36	view →
READ	OS	Tertile	All	0.205	0.693	.029	27	view →
COAD	OS	Tertile	IV	0.056	0.659	.002	18	view →
LUAD	DFS	Tertile	III,IV	0.232	0.690	.002	18	view →
ESCA	DFS	Tertile	All	0.148	0.673	.040	18	view →
HNSC	DFS	Tertile	III,IV	0.237	0.515	.022	12	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	9	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

IGKV2D-19–KICH (DFS)

Open the KICH breakdown →