IGKV2D-14

Across TCGA patient cohorts, IGKV2D-14 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,693 significant associations in total. STAD shows the largest number of these associations.

The most reproducible IGKV2D-14-associated GO terms across cancer lineages are Tissue homeostasis, Immunoglobulin production, and Negative regulation of small GTPase mediated signal transduction. Each is linked with IGKV2D-14 in more than 5 cancer types. Because this analysis shows association rather than direction, both IGKV2D-14-to-partner and partner-to-IGKV2D-14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tissue homeostasis grouped by IGKV2D-14-low versus IGKV2D-14-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2D-14→partner) and Y-score (partner→IGKV2D-14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Tissue homeostasis →	+0.101	+0.046	<.001	.002	3	6
STAD	Immunoglobulin production →	+0.124	+0.048	<.001	.002	3	6
STAD	Negative regulation of small GTPase mediated signal transduction →	+0.106	+0.064	<.001	.001	3	6
STAD	Leukocyte apoptotic process →	+0.138	+0.045	<.001	.003	3	6
STAD	Leukocyte mediated cytotoxicity →	+0.110	+0.045	<.001	.003	3	5
STAD	B cell mediated immunity →	+0.138	+0.031	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,693 associations by consensus.

Tissue homeostasis by IGKV2D-14 expression — STAD

Explore this box plot interactively →