IGKV2D-14

Across TCGA pan-cancer cohorts, IGKV2D-14 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated IGKV2D-14 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher IGKV2D-14 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV2D-14 expression acts as an unfavorable survival marker.

UVM, KIRC, and ESCA are the cancer types where IGKV2D-14 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.104	0.858	<.001	99	view →
KIRC	DFS	Tertile	III,IV	0.200	0.758	<.001	78	view →
ESCA	OS	Tertile	II,III,IV	0.253	0.711	<.001	72	view →
STAD	DFS	Tertile	III,IV	0.155	0.588	<.001	66	view →
LUAD	DFS	Tertile	II,III,IV	0.211	0.666	<.001	54	view →
OV	DFS	Tertile	II,III,IV	0.313	0.543	.047	36	view →
LGG	OS	Tertile	All	0.173	0.830	<.001	36	view →
LAML	DFS	Tertile	All	0.047	0.588	<.001	18	view →
KIRP	OS	Tertile	II,III,IV	0.199	0.771	.030	9	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

IGKV2D-14–UVM (OS)

Open the UVM breakdown →