IGKV2D-10

Across TCGA pan-cancer cohorts, IGKV2D-10 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated IGKV2D-10 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV2D-10 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV2D-10 expression acts as an unfavorable survival marker, although some lineages such as BRCA show a favorable association.

HNSC, LIHC, and LUAD are the cancer types where IGKV2D-10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	III,IV	0.384	0.703	.001	42	view →
LIHC	OS	Tertile	II,III,IV	0.119	0.617	.021	27	view →
LUAD	DFS	Tertile	IV	0.342	0.893	<.001	18	view →
BRCA	OS	Tertile	II,III,IV	0.991	0.953	.027	12	view →
THCA	DFS	Tertile	III,IV	0.749	0.939	.004	12	view →
LUSC	OS	Tertile	III,IV	0.163	0.662	.016	12	view →
UCEC	DFS	Tertile	All	0.819	0.901	.029	12	view →
UVM	OS	Tertile	All	0.315	0.711	.049	9	view →
SKCM	OS	Tertile	II,III,IV	0.698	0.851	.017	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

IGKV2D-10–HNSC (OS)

Open the HNSC breakdown →